Circadian Sleep (Melatonin & Nobiletin)

Life Extension

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Circadian Sleep (Melatonin & Nobiletin) 30 Capsules

Aging, hectic modern lifestyles, and other factors can disrupt our circadian clocks, which can affect our health. So Life Extension developed Circadian Sleep (Melatonin & Nobiletin) formula to help restore these natural rhythms.

Circadian Sleep (Melatonin & Nobiletin) MicroActive® Melatonin supports the central clock in the brain, while nobiletin young citrus peel extract promotes healthy peripheral clocks, which control the rest of the body. 

Melatonin for healthy sleep-wake cycling

Peripheral circadian clocks exist in virtually every cell of our bodies and are organized hierarchically, with the central clock setting the pace by regulating healthy sleep-wake cycles. Melatonin, known as the “sleep hormone,” is primarily synthesized at night in the brain by the pineal gland. Melatonin ensures that the central clock is properly supporting sleep-wake cycles and aligning the peripheral clocks with the sleep-wake cycles for whole-body health.

The first step to healthy, whole-body circadian rhythms is to restore that central clock with melatonin. 

Nobiletin for healthy peripheral circadian rhythms

Peripheral circadian clocks in various organs govern essential biological processes: heart rate, body temperature, hormone release, blood pressure, liver, kidney and pancreatic function and more. 

Nobiletin is a polymethoxylated flavone isolated from young citrus peel. Results from a recent pre-clinical study suggest that nobiletin may also help positively support peripheral circadian rhythms. It does so by directly activating a unique set of receptors widely expressed throughout the body and known to play a key role in supporting circadian rhythms. It has also been shown to exhibit neuroprotective and antioxidant properties as well as promote a healthy inflammatory response.

Healthy expression of genes controlling circadian rhythms supports metabolic, cognitive, liver and kidney health and also helps maintain healthy blood pressure, cholesterol and triglyceride levels already within the normal range.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. 

Supplement Facts

Serving Size 1 liquid vegetarian capsule

Amount Per Serving

Nobiletin [from young citrus fruit (peel)]

50 mg

Melatonin (as MicroActive®)

1.5 mg

Other ingredients: medium chain triglycerides, vegetable capsule (hydroxypropyl methylcellulose, chlorophyllin), microcrystalline cellulose, sodium alginate, carnauba wax, silica.


MicroActive® Melatonin is a registered trademark of Bioactives LLC.

Dosage and Use

  • Take one (1) capsule daily, before bedtime, or as recommended by a healthcare practitioner.
  • Melatonin is naturally secreted from the pineal gland at night, and should be taken at night for optimal results.


Do not consume alcohol, drive or operate machinery after taking this product.


  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Actual Size

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