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Life Extension

Pro-Resolving Mediators

Pro-Resolving Mediators

Regular price $21.00 USD
Regular price $28.00 USD Sale price $21.00 USD
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This formula uses SPM precursors derived from marine oil to support healthy tissue rejuvenation, promote the natural clearing of cellular debris and help maintain a healthy balance of cytokine compounds.

A whole-body health regimen should include nutrients that help inhibit inflammation to support whole-body health, as well as those that help maintain the body’s healthy post-inflammatory response. The SPM compounds in this innovative supplement do just that: promote a healthy post-inflammatory response.

Derived from marine oil

Resolvins and maresins are the two principle kinds of specialized pro-resolving mediators, or SPMs. They’re created by your body from fatty acids such as EPA and DHA omega-3.

So why not just take a fish oil supplement? Because fish oil is not completely converted to SPMs, and may not support SPM levels sufficiently. Fish oil and SPMs also have distinct activities in the body and are not interchangeable. Research indicates that ingesting SPMs and precursors like 17-HDHA and 18-HEPE is better than taking fish oil when a healthy post-inflammatory response is required in order to promote whole-body health.


The body’s natural biological response to inflammation can cause cellular debris. SPMs encourage the body’s existing pathways for naturally identifying and removing cellular debris, as well as recycling cells that no longer function optimally.


Cytokines are a family of chemical compounds released by immune cells to help govern a variety of biological processes. The body naturally maintains a balance between the different types of cytokine compounds—a hallmark of healthy aging. SPMs help maintain a healthy balance between cytokines. Maintaining this balance helps promote whole-body health.


It is important to support the natural biological process for rejuvenating youthful, healthy system-wide functionality. SPMs do just that by promoting the body’s natural processes for revitalizing healthy skin, organs, and other vital tissues.

Part of a healthy whole-body health regimen

Pro-Resolving Mediators helps maintain the body’s healthy post-inflammatory response. We recommend taking SPMs as part of a comprehensive whole-body health-support regimen, along with Curcumin Elite™ Turmeric Extract. Try Pro-Resolving Mediators today.

Not for sale outside the USA.

 These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. 

Serving Size 1 softgels

Amount Per Serving



Total Fat

0.5 g


<5 mg

Marine Lipid Concentrate

500 mg

[providing 300 mcg of Pro-Resolving Mediators including

18-hydroxyeicosapentaenoic acid (18-HEPE)

17-hydroxydocosahexaenoic acid (17-HDHA)

14-hydroxydocosahexaenoic acid (14-HDHA)]


Other ingredients: highly refined marine oil concentrate, (squid, anchovy, sardine, herring, mackerel), gelatin, olive oil, glycerin, purified water, lemon flavor, mixed tocopherols.



Dosage and Use
  • Take one (1) softgel daily, or as recommended by a healthcare practitioner.
  • Store tightly closed in a cool, dry place.


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